Most papers are machine-translated to English; some are originally in English.
Showing 50 of 98 papers in Clinical Medicine
Abstract Background: The Chinese Visceral Adiposity Index (CVAI) is a novel and simplified metric for evaluating human visceral fat, which is closely associated with cardiovascular and metabolic diseases. Currently, research regarding the correlation between CVAI and diabetes remains limited. Object…
Abstract Background: Colorectal adenoma resection is an effective way to reduce the incidence of colorectal cancer. Currently, the recurrence rate of advanced colorectal neoplasia (ACRN) within 1 year after colorectal adenoma resection is high, and there is a lack of research on the construction of …
Diabetic neuropathy (DN) is the most common and devastating chronic complication of diabetes, among which autonomic neuropathy has garnered significant attention due to its involvement in the dysfunction of multiple organ systems. Pathological mechanisms such as metabolic abnormalities, oxidative st…
Abstract Background: Sarcopenia has a significant impact on the treatment and prognosis of patients with colorectal cancer, and dietary patterns are significantly associated with the condition. Clarifying the correlation between Chinese healthy dietary patterns and sarcopenia is of great significanc…
The occurrence of acute kidney injury on the basis of multiple coexisting chronic conditions in elderly individuals (also known as "geriatric multimorbidity") is clinically very common. Early and timely intervention with rehabilitation therapy can enhance patients' quality of life and improve clinic…
Abstract Background: In Traditional Chinese Medicine, depression falls under the category of emotional disorders, and its pathogenesis can be explained by the theory of "Interdependence between Kidney and Brain." Whether the Kidney-Tonifying and Brain-Strengthening acupuncture therapy can be used to…
Abstract Background: Surgical strategies and the risks of recurrence and metastasis differ significantly between benign and malignant phyllodes tumors of the breast (PTB). Preoperative differentiation between benign and malignant status is crucial for treatment decision-making. Traditional ultrasoun…
Vaccine-preventable diseases impose a heavy health burden on adults, and numerous shortcomings in China's current adult immunization planning urgently need to be addressed and resolved. The "Expert Consensus on Health Promotion Strategies for Adult Vaccination in China" was led by the Institute for …
Abstract Background: Colorectal cancer is the malignant tumor with the second highest incidence rate globally. Research indicates that iron metabolism is involved in multiple stages of tumor progression, including tumor cell proliferation and regulation of the immune microenvironment. In clinical pr…
Breast cancer remains one of the most significant global health challenges. Patient survival rates drop drastically when cancer cells spread to adjacent or distant tissues and organs, resulting in distant metastasis. Consequently, early diagnosis and the prediction of malignant potential are critica…
Background: China is currently leveraging artificial intelligence (AI) technology to enhance the standardization and homogenization of primary health services, driving universal health coverage and demonstrating global leadership in the field of digital health. Objective: To empirically reveal the m…
Abstract Background: Computed tomography-derived fractional flow reserve (CT-FFR) has demonstrated excellent diagnostic performance; however, the consistency between CT-FFR values calculated by different deep learning algorithms has not been evaluated. Objective: This study aims to evaluate the cons…
Background Good medication adherence can significantly reduce the risk of recurrence in stroke patients and is critical to secondary prevention in this population. However, existing research has primarily focused on short-term medication use and adherence behaviors among rural stroke patients, while…
Background Primary Sjögren's disease (pSjD) is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, mainly manifesting as dry mouth and dry eyes, and can involve multiple systems. Epidemiological surveys show its prevalence is approximately 0.06%~0.08%, and is i…
Background Accurate assessment of immune-related adverse events (irAEs) in cancer patients through patient-reported outcomes facilitates early identification of irAEs and timely development and implementation of targeted interventions, which is essential for ensuring continuous treatment and favorab…
Background Currently, six ALK inhibitors (including crizotinib, alectinib, ceritinib, brigatinib, ensartinib, and lorlatinib) have been approved for first-line treatment of ALK-positive advanced non-small cell lung cancer, yet clinical selection remains challenging. Objective To comprehensively eval…
Background Traditional Chinese medicine theory holds that syndrome distribution is closely related to region, but there is currently a lack of clinical studies on the differences in clinical characteristics and syndrome distribution among lung cancer patients in different regions. Objective To analy…
Colorectal cancer, as one of the malignant tumors with persistently high incidence and mortality rates worldwide, poses a serious threat to human health. Moreover, the early diagnosis rate of colorectal cancer is relatively low, and many patients are already in middle and advanced stages at the time…
Background Chinese Visceral Adiposity Index (CVAI) is a novel obesity indicator that has been confirmed to be closely associated with prehypertension and hypertension. However, current research on the correlation between CVAI and nocturnal hypertension (NH) in young and middle-aged adults is lacking…
Background As population aging intensifies in China, the issue of frailty among older adults has become increasingly prominent, rendering research on its prevention and intervention particularly critical. Currently, most studies have not explored the dynamic relationship between physical activity tr…
Isolated hypothyroxinemia in pregnancy represents a manifestation of thyroid hormone deficiency during gestation, which may impair fetal neurodevelopment and increase the risks of miscarriage, preterm delivery, and gestational diabetes mellitus; however, its underlying mechanisms, optimal therapeuti…
Background Risperidone, as an antipsychotic agent, is widely used in the treatment of schizophrenia and other mental disorders. Although therapeutic drug monitoring (TDM) of risperidone plasma concentrations has been implemented for many years both domestically and internationally, consensus has not…
Background Currently, cognitive impairment has become one of the risk factors for disability and death among older adults. Studies have found a correlation between parental literacy and cognitive function, while research on the mediating role of socioeconomic status (SES) between the two is relative…
Background: Idiopathic pulmonary fibrosis (IPF) has a complex pathogenesis, limited treatment options, and poor prognosis, making the search for safe and effective therapeutic targets crucial. Objective: To investigate the regulatory effect of Neuropilin-1 (Nrp1) on mouse pulmonary fibroblast (MPF) …
Background As population aging intensifies, the incidence and impact of geriatric syndromes have gradually attracted widespread attention, with sarcopenic obesity (SO) emerging as a recent research focus. Studies have indicated that blood lipid levels may be an important influencing factor for SO; h…
Acute myocardial infarction (AMI), as one of the leading causes of mortality and disability from cardiovascular disease globally, has made the optimization of its postoperative long-term management strategies a focal issue in the medical community. Exercise-based cardiac rehabilitation (EBCR), as a …
Heart failure represents the end-stage manifestation of multiple cardiac diseases with a poor prognosis, and its risk of onset increases significantly with advancing age and cardiomyocyte senescence. The mammalian target of rapamycin (mTOR) pathway plays a pivotal role in the pathophysiology of card…
Childhood and adolescent obesity represents a severe global public health challenge that not only compromises current health but also increases the risk of cardiometabolic diseases in adulthood. In 2024, the Italian Society of Pediatric Endocrinology and Diabetology published a position paper titled…
Background Chronic obstructive pulmonary disease (COPD) is one of the major diseases that seriously threaten public health in China. Owing to the specific structural and functional characteristics of the kidneys, COPD patients are prone to renal function impairment; however, research on the related …
This paper focuses on the issue of delayed completion in standardized general practice residency training (GP residency training), conducting a cross-national comparative analysis of the training systems, current status of delays, causes, and reform strategies in 11 representative developed and deve…
Background: Coronary heart disease is a prevalent cardiovascular disease worldwide that significantly impacts patients' quality of life and survival rates. Cardiac rehabilitation constitutes a critical component in the recovery trajectory of coronary heart disease patients and is of paramount import…
The impact of cardiovascular diseases (CVD) and their risk factors on population health is becoming increasingly prominent, with the incidence of CVD continuing to rise. The economic burden imposed by CVD on both individuals and society is mounting, constituting a major public health challenge that …
Abstract Objective: To investigate the application value of arteriovenous blood gas differences in neonatal sepsis and to provide a new objective indicator for early diagnosis of neonatal sepsis. Methods: This study selected neonates with sepsis hospitalized in the Neonatology Department of Yuebei P…
Background: In clinical practice, children with asthma-related symptoms such as wheezing, cough, and chest tightness first undergo pulmonary ventilation function testing. When forced expiratory volume in the first second (FEV1) <70%, it indicates significant airflow limitation or airway obstruction,…
Amidst the global wave of digital transformation, the data revolution in the healthcare industry is accelerating, with countries actively introducing digital policies to drive medical data development. This paper focuses on the construction of digital policy-driven medical data spaces, systematicall…
Hypertension is the leading cause of stroke mortality and the primary contributor to the burden of stroke-related disability-adjusted life years (DALYs). As the most important modifiable risk factor, effective prevention and control of hypertension has become a core task in primary and secondary str…
Background: Special education rehabilitation therapy is the primary approach for improving core symptoms of autism spectrum disorder (ASD); however, most children with ASD suffer from comorbid gastrointestinal dysfunctions such as constipation, abdominal pain, and nausea, which severely impact their…
Background Hearing loss is a common health issue among middle-aged and elderly individuals, affecting quality of life and social interaction, and is associated with the risk of cognitive decline. In recent years, population aging in China has intensified, with the proportion of middle-aged and elder…
Background The diagnostic and therapeutic capacity for osteoporosis in Shanghai's community health service institutions remains unclear, lacking systematic evaluation and monitoring. Objective To understand the current status of osteoporosis diagnosis, treatment, and management in Shanghai's communi…
Background: Drug use disorder has become a global public health challenge that threatens people's lives and health, increases disease burden, and constrains economic development and social progress. The disease burden caused by different types of drug use varies, and identifying priorities for preve…
Background In accordance with the medical-preventive integration work deployment, and building upon the implementation of basic public health services, Longhua District of Shenzhen launched a pilot program of "digitalization + health management" generalist-specialist collaborative services across th…
Background Nervous system diseases severely impair patients' quality of life, with complex etiologies involving multiple factors such as genetics, infection, and immunity. In recent years, research on the involvement of gut microbiota in the pathogenesis and progression of nervous system diseases vi…
Background Hemorrhoids are one of the common diseases in colorectal and anal surgery, and injection therapy is a commonly used treatment modality. However, nationwide data regarding the depth of application and standardized usage of injection therapy are currently lacking, necessitating this investi…
Background: With the continuous deepening of the family doctor contract service system, how to effectively extend family doctor contract services to functional building populations has emerged as a key focus. Understanding the demand characteristics of this population is a critical approach for deve…
Immune-mediated inflammatory diseases (IMIDs) commonly affect women of childbearing age, and the impact of therapeutic agents on pregnancy outcomes, fetal development, and infants complicates pharmacotherapeutic decision-making during pregnancy and lactation. This article reviews the latest domestic…
The prevalence of obesity-related hypertension has risen markedly worldwide, emerging as a focal point of attention in the current medical community. Obesity increases the difficulty of controlling hypertension, promotes cardiovascular and cerebrovascular injury, and aggravates disease burden. Abnor…
Background: The application of deep learning in medical imaging faces challenges such as time-consuming and labor-intensive data annotation, which restricts the efficiency of its clinical translation. Objective: To investigate the feasibility and efficacy of a deep learning network that integrates t…
Background In recent years, medical research has identified a certain association between Relative Fat Mass (RFM) and cardiovascular disease (CVD). However, nationwide cohort studies on the relationship between RFM and CVD incidence risk in Chinese populations remain limited. Objective To analyze th…
Stroke represents one of the principal causes of the global burden of disease and mortality, concurrently ranking as the leading cause of death in the Chinese population, and has emerged as a major public health problem threatening public health and social development. Prior research has demonstrate…
背景 Traditional Chinese medicine (TCM) possesses profound theoretical foundations and extensive practical applications in the field of maternal and child health, with the state actively promoting the development of TCM work in this domain. However, issues such as insufficient knowledge of perinatal T…
