Most papers are machine-translated to English; some are originally in English.
Showing 50 of 150 papers
Background: Idiopathic pulmonary fibrosis (IPF) has a complex pathogenesis, limited treatment options, and poor prognosis, making the search for safe and effective therapeutic targets crucial. Objective: To investigate the regulatory effect of Neuropilin-1 (Nrp1) on mouse pulmonary fibroblast (MPF) …
Background As population aging intensifies, the incidence and impact of geriatric syndromes have gradually attracted widespread attention, with sarcopenic obesity (SO) emerging as a recent research focus. Studies have indicated that blood lipid levels may be an important influencing factor for SO; h…
Acute myocardial infarction (AMI), as one of the leading causes of mortality and disability from cardiovascular disease globally, has made the optimization of its postoperative long-term management strategies a focal issue in the medical community. Exercise-based cardiac rehabilitation (EBCR), as a …
Heart failure represents the end-stage manifestation of multiple cardiac diseases with a poor prognosis, and its risk of onset increases significantly with advancing age and cardiomyocyte senescence. The mammalian target of rapamycin (mTOR) pathway plays a pivotal role in the pathophysiology of card…
Childhood and adolescent obesity represents a severe global public health challenge that not only compromises current health but also increases the risk of cardiometabolic diseases in adulthood. In 2024, the Italian Society of Pediatric Endocrinology and Diabetology published a position paper titled…
Background Chronic obstructive pulmonary disease (COPD) is one of the major diseases that seriously threaten public health in China. Owing to the specific structural and functional characteristics of the kidneys, COPD patients are prone to renal function impairment; however, research on the related …
This paper focuses on the issue of delayed completion in standardized general practice residency training (GP residency training), conducting a cross-national comparative analysis of the training systems, current status of delays, causes, and reform strategies in 11 representative developed and deve…
Background: Coronary heart disease is a prevalent cardiovascular disease worldwide that significantly impacts patients' quality of life and survival rates. Cardiac rehabilitation constitutes a critical component in the recovery trajectory of coronary heart disease patients and is of paramount import…
The impact of cardiovascular diseases (CVD) and their risk factors on population health is becoming increasingly prominent, with the incidence of CVD continuing to rise. The economic burden imposed by CVD on both individuals and society is mounting, constituting a major public health challenge that …
Abstract Objective: To investigate the application value of arteriovenous blood gas differences in neonatal sepsis and to provide a new objective indicator for early diagnosis of neonatal sepsis. Methods: This study selected neonates with sepsis hospitalized in the Neonatology Department of Yuebei P…
Poor sleep in older adults is closely associated with multiple health outcomes. If primary healthcare institutions strengthen sleep health and rehabilitation management on the basis of existing elderly health management, it will help prevent and delay the onset and progression of many chronic diseas…
Background: In clinical practice, children with asthma-related symptoms such as wheezing, cough, and chest tightness first undergo pulmonary ventilation function testing. When forced expiratory volume in the first second (FEV1) <70%, it indicates significant airflow limitation or airway obstruction,…
Amidst the global wave of digital transformation, the data revolution in the healthcare industry is accelerating, with countries actively introducing digital policies to drive medical data development. This paper focuses on the construction of digital policy-driven medical data spaces, systematicall…
Hypertension is the leading cause of stroke mortality and the primary contributor to the burden of stroke-related disability-adjusted life years (DALYs). As the most important modifiable risk factor, effective prevention and control of hypertension has become a core task in primary and secondary str…
Background: Special education rehabilitation therapy is the primary approach for improving core symptoms of autism spectrum disorder (ASD); however, most children with ASD suffer from comorbid gastrointestinal dysfunctions such as constipation, abdominal pain, and nausea, which severely impact their…
Background As understanding of endometriosis pain management deepens, an increasing number of domestic and international guidelines/expert consensuses have emerged, providing important guidance and reference for clinical practice. However, their quality varies considerably, necessitating systematic …
The application of artificial intelligence in the medical domain has emerged as a pivotal driving force for bridging the chasm between basic research and clinical practice, concurrently reshaping diagnostic and therapeutic paradigms. While transforming medical decision-making workflows and doctor-pa…
Background The irrational use of antibiotics among pediatric patients and their parents following hospital discharge represents a significant problem. Providing accurate antibiotic medication guidance and educational outreach to children and parents constitutes a crucial intervention for improving p…
Background Hearing loss is a common health issue among middle-aged and elderly individuals, affecting quality of life and social interaction, and is associated with the risk of cognitive decline. In recent years, population aging in China has intensified, with the proportion of middle-aged and elder…
Background The diagnostic and therapeutic capacity for osteoporosis in Shanghai's community health service institutions remains unclear, lacking systematic evaluation and monitoring. Objective To understand the current status of osteoporosis diagnosis, treatment, and management in Shanghai's communi…
Background: Drug use disorder has become a global public health challenge that threatens people's lives and health, increases disease burden, and constrains economic development and social progress. The disease burden caused by different types of drug use varies, and identifying priorities for preve…
Background In accordance with the medical-preventive integration work deployment, and building upon the implementation of basic public health services, Longhua District of Shenzhen launched a pilot program of "digitalization + health management" generalist-specialist collaborative services across th…
Background Nervous system diseases severely impair patients' quality of life, with complex etiologies involving multiple factors such as genetics, infection, and immunity. In recent years, research on the involvement of gut microbiota in the pathogenesis and progression of nervous system diseases vi…
[Objective] To translate and culturally adapt the Attitude Scale Towards the Use of Artificial Intelligence Technologies in Nursing (ASUAITIN) and examine its reliability and validity, thereby providing an assessment instrument for evaluating clinical nurses' attitudes toward the application of arti…
Ischemic stroke, as one of the leading causes of disability and mortality worldwide, has witnessed significant advances in research on prognostic biomarkers in recent years. This study reviews the mechanisms of action and research progress on the utility of various biomarkers, including hematologica…
Cardiovascular disease is one of the major diseases threatening women's health, and postmenopausal women are a high-risk population for cardiovascular disease. The decline in estrogen levels after menopause may promote the accumulation of visceral fat, and increased visceral fat is closely associate…
Background Hemorrhoids are the most common disease in anorectal surgery, with a large patient population. The integrated traditional Chinese and Western medicine approach demonstrates significant advantages in clinical practice. Currently, there is a lack of high-quality guidelines or recommended st…
Post-stroke cognitive impairment (PSCI) is a common sequela in stroke patients, severely affecting their quality of life and often being overlooked. The high incidence, insidious symptoms, and heavy social burden of PSCI have made it a research priority. Understanding the prevalence and related fact…
Background Under the government's high attention to the development of general practice, tertiary general hospitals have successively established general practice departments. The disciplinary characteristics of general practice departments give them significant advantages in the admission and manag…
Background Hemorrhoids are one of the common diseases in colorectal and anal surgery, and injection therapy is a commonly used treatment modality. However, nationwide data regarding the depth of application and standardized usage of injection therapy are currently lacking, necessitating this investi…
Background: With the continuous deepening of the family doctor contract service system, how to effectively extend family doctor contract services to functional building populations has emerged as a key focus. Understanding the demand characteristics of this population is a critical approach for deve…
Immune-mediated inflammatory diseases (IMIDs) commonly affect women of childbearing age, and the impact of therapeutic agents on pregnancy outcomes, fetal development, and infants complicates pharmacotherapeutic decision-making during pregnancy and lactation. This article reviews the latest domestic…
The prevalence of obesity-related hypertension has risen markedly worldwide, emerging as a focal point of attention in the current medical community. Obesity increases the difficulty of controlling hypertension, promotes cardiovascular and cerebrovascular injury, and aggravates disease burden. Abnor…
Background: The application of deep learning in medical imaging faces challenges such as time-consuming and labor-intensive data annotation, which restricts the efficiency of its clinical translation. Objective: To investigate the feasibility and efficacy of a deep learning network that integrates t…
Background In recent years, medical research has identified a certain association between Relative Fat Mass (RFM) and cardiovascular disease (CVD). However, nationwide cohort studies on the relationship between RFM and CVD incidence risk in Chinese populations remain limited. Objective To analyze th…
Stroke represents one of the principal causes of the global burden of disease and mortality, concurrently ranking as the leading cause of death in the Chinese population, and has emerged as a major public health problem threatening public health and social development. Prior research has demonstrate…
背景 Traditional Chinese medicine (TCM) possesses profound theoretical foundations and extensive practical applications in the field of maternal and child health, with the state actively promoting the development of TCM work in this domain. However, issues such as insufficient knowledge of perinatal T…
Background Cancer patients often develop symptoms such as muscle wasting, yet the underlying pathological mechanisms remain incompletely elucidated. Objective To investigate the pathological mechanisms of cancer-associated skeletal muscle injury and to examine the therapeutic effect of the Yiqi Chut…
Background Hypertension, diabetes mellitus, and dyslipidemia ("the three highs") frequently coexist with metabolic-associated fatty liver disease, exerting mutual influence and significantly increasing the risk of adverse cardiovascular and hepatic outcomes. Currently, standardized diagnostic and th…
Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are respiratory diseases with high incidence and mortality. COPD is an independent high-risk factor for LC, and the two conditions influence each other, posing challenges to clinical diagnosis and treatment. Early detection and treatm…
A section titled "Learning from Nurse Liang Jielian in 1954" in the 70th Anniversary Special Issue of Health News introduced the historical facts of Liang's creation of the painless injection method and its promotion, noting that "this was the most heartwarming scene in China's nursing community of …
Background Frailty is an age-related geriatric syndrome, and the prevalence of frailty among older adults in China is relatively high and shows an increasing trend year by year. Obesity is closely associated with the occurrence and development of multiple diseases, but its relationship with frailty …
Obesity is frequently complicated by metabolism-related diseases, which constitute important etiological factors or risk factors and are associated with adverse prognosis; effective weight reduction can improve or even remit these comorbidities. Lifestyle intervention alone demonstrates suboptimal e…
Background: As an emerging technology, large language models are gradually gaining recognition and application among the general public. Thyroid cancer is a common type of malignant tumor in China, and patients have a high demand for thyroid cancer popular science information; however, there is stil…
Background: Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant widely used for the treatment of major depression, generalized anxiety disorder, and depression comorbidities. The Chinese Expert Consensus on the Clinical Application of Therapeutic Drug Monitoring in Psy…
Background In recent years, diabetic foot has become a significant cause of disability and mortality among diabetic patients. With advancements in era and technology, the understanding and research of diabetic foot in both modern medicine and traditional Chinese medicine have gradually deepened, fur…
Background: Acute myocardial infarction (AMI) is one of the leading causes of death worldwide. Percutaneous coronary intervention (PCI) is the preferred clinical treatment for most AMI patients; however, they still face a high risk of heart failure (HF) after surgery, with poor prognosis that severe…
Background Endoscopic retrograde cholangiopancreatography (ERCP) is the standard method for diagnosing and treating pancreaticobiliary diseases, but post-ERCP pancreatitis (PEP) represents a serious complication. Non-steroidal anti-inflammatory drugs (NSAIDs) may play a role in PEP prevention due to…
Background: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) constitutes a common complication of rheumatoid arthritis (RA), affecting 20%~50% of RA patients and substantially increasing mortality risk. Currently, clinically effective and safe therapeutic agents with clear targets …
Background Mycoplasma pneumoniae pneumonia (MPP) is a common community-acquired pneumonia in children in China. Its clinical features and prognosis are closely related to age and imaging progression, yet systematic studies combining age stratification with imaging analysis remain insufficient. Objec…
