Most papers are machine-translated to English; some are originally in English.
Showing 48 of 98 papers in Clinical Medicine
Background Cancer patients often develop symptoms such as muscle wasting, yet the underlying pathological mechanisms remain incompletely elucidated. Objective To investigate the pathological mechanisms of cancer-associated skeletal muscle injury and to examine the therapeutic effect of the Yiqi Chut…
Background Hypertension, diabetes mellitus, and dyslipidemia ("the three highs") frequently coexist with metabolic-associated fatty liver disease, exerting mutual influence and significantly increasing the risk of adverse cardiovascular and hepatic outcomes. Currently, standardized diagnostic and th…
Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are respiratory diseases with high incidence and mortality. COPD is an independent high-risk factor for LC, and the two conditions influence each other, posing challenges to clinical diagnosis and treatment. Early detection and treatm…
Background Frailty is an age-related geriatric syndrome, and the prevalence of frailty among older adults in China is relatively high and shows an increasing trend year by year. Obesity is closely associated with the occurrence and development of multiple diseases, but its relationship with frailty …
Obesity is frequently complicated by metabolism-related diseases, which constitute important etiological factors or risk factors and are associated with adverse prognosis; effective weight reduction can improve or even remit these comorbidities. Lifestyle intervention alone demonstrates suboptimal e…
Background: As an emerging technology, large language models are gradually gaining recognition and application among the general public. Thyroid cancer is a common type of malignant tumor in China, and patients have a high demand for thyroid cancer popular science information; however, there is stil…
Background: Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant widely used for the treatment of major depression, generalized anxiety disorder, and depression comorbidities. The Chinese Expert Consensus on the Clinical Application of Therapeutic Drug Monitoring in Psy…
Background In recent years, diabetic foot has become a significant cause of disability and mortality among diabetic patients. With advancements in era and technology, the understanding and research of diabetic foot in both modern medicine and traditional Chinese medicine have gradually deepened, fur…
Background: Acute myocardial infarction (AMI) is one of the leading causes of death worldwide. Percutaneous coronary intervention (PCI) is the preferred clinical treatment for most AMI patients; however, they still face a high risk of heart failure (HF) after surgery, with poor prognosis that severe…
Background Endoscopic retrograde cholangiopancreatography (ERCP) is the standard method for diagnosing and treating pancreaticobiliary diseases, but post-ERCP pancreatitis (PEP) represents a serious complication. Non-steroidal anti-inflammatory drugs (NSAIDs) may play a role in PEP prevention due to…
Background: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) constitutes a common complication of rheumatoid arthritis (RA), affecting 20%~50% of RA patients and substantially increasing mortality risk. Currently, clinically effective and safe therapeutic agents with clear targets …
Background Mycoplasma pneumoniae pneumonia (MPP) is a common community-acquired pneumonia in children in China. Its clinical features and prognosis are closely related to age and imaging progression, yet systematic studies combining age stratification with imaging analysis remain insufficient. Objec…
Background IgA vasculitis nephritis (IgAVN) represents one of the common systemic small-vessel vasculitides in childhood, yet comprehensive investigations into the relationship between hematological indices and urinary protein quantification in pediatric patients remain limited. Objective This study…
Background: Polycystic ovary syndrome (PCOS) is an extremely prevalent endocrine disorder among women of reproductive age. Obese PCOS patients often present with insulin resistance, leading to disturbances in glucose and lipid metabolism, abnormal pancreatic islet function, which subsequently causes…
Brand plays an increasingly important role in the management of community health service centers. By implementing brand strategy, these centers can attract more residents to "seek treatment for minor illnesses within the community," which is of great significance for the rational allocation of medic…
Background: For patients with heart failure, early assessment and prompt treatment can prevent adverse cardiac events, and effective diagnostic evaluation tools are particularly important for such patients; phonocardiography (ACG) serves as an efficient and non-invasive bedside screening tool for as…
Intracerebral hemorrhage (ICH) is a stroke subtype with high mortality and disability rates. Ferroptosis plays a crucial role in secondary injury following ICH. Mitochondria, as the hub of cellular metabolism and energy production, are critically involved in ferroptosis. Investigating the role of mi…
Background: Cardiometabolic diseases are closely associated with depression. Primary care management of cardiometabolic diseases has achieved initial scale; however, there is insufficient attention to psychological issues such as depression in patients, and a lack of simple, accurate, and efficient …
The high-quality development of national basic public health services is constrained by bottlenecks including insufficient high-quality resources at the primary level and limited diagnostic and treatment capacities. In accordance with the deployment of medical-preventive integration, and relying on …
Cerebral ischemia-reperfusion injury refers to the secondary damage to ischemic brain tissue that occurs during the restoration of cerebral blood flow following interruption, resulting from multiple biological processes including energy metabolism disturbance, oxidative stress, free radical damage, …
Background Post-stroke dysphagia is one of the common and serious complications of stroke, which can significantly reduce patients' quality of life and increase mortality risk. Current research suggests that multiple factors are associated with the prognosis of post-stroke dysphagia, but the quality…
Arterial pressure, structure, and function assessment constitutes an essential component of cardiovascular health management. In recent years, various non-invasive evaluation techniques have been applied in clinical practice; however, the usage details, advantages, and limitations of these technolog…
Background: The "3+2" order-oriented assistant general practitioners in Jiangsu Province play an important role in primary healthcare, but face issues such as low contract fulfillment rates and insufficient professional identity, urgently needing to improve work well-being. Objective: To understand …
Background: Heart failure (HF) represents a major chronic disease that seriously endangers global health, with coronary heart disease (CHD) being its most common cause. Constructing risk prediction models based on risk factors for HF complicating CHD can assist healthcare professionals in early iden…
Background Currently, cancer treatment has undergone tremendous transformation, with many cancer patients achieving long-term survival in a chronic disease model. Studies have shown that numerous cancer survivors die from non-neoplastic factors, among which cardiovascular disease (CVD) represents a …
Background: Patients with interstitial lung disease are prone to acute exacerbations, with infection being one of the important triggers. Patients experiencing acute exacerbation have high mortality rates and poor prognosis, and research on this population is currently limited in China. Objective: T…
Background: Blood stasis syndrome is an important concurrent syndrome of primary Sjögren's syndrome (pSS), yet research on its quantitative characteristics and clinical associations remains insufficient. Objective: To investigate the quantitative characteristics of blood stasis syndrome in pSS patie…
Background Acute ST-segment elevation myocardial infarction (STEMI) is associated with high mortality and disability rates. Percutaneous coronary intervention (PCI) is an important revascularization method that can improve prognosis. However, some patients experience recurrent angina after PCI, affe…
Background Health issues among community-dwelling elderly populations have gradually become an important topic of widespread social concern, urgently requiring multi-subject collaborative intervention to construct a scientific and effective health support system. Objective To understand the health s…
Background Hypertension is a major cardiovascular disease. The Life's Essential 8 (LE8) score, a recently proposed cardiovascular health assessment indicator, and its relationship with the risk of hypertension remains unclear. Objective To investigate the relationship between LE8 score and the risk …
Background: In recent years, the incidence and prevalence of metabolic-associated fatty liver disease (MAFLD) have been increasing annually, with over a quarter of the global population affected by MAFLD. Type 2 diabetes mellitus (T2DM) is closely associated with MAFLD; however, there are currently …
Background The high incidence of type 2 diabetes mellitus in older adults has become a severe global public health problem. Diabetes causes substantial damage to cognitive function, and there remains a lack of simple indicators for its early monitoring and identification, necessitating further explo…
Background: Alzheimer's disease (AD) is a complex neurodegenerative disease that imposes a heavy burden on patients and their families. In recent years, clinical studies on traditional Chinese medicine preparations for AD treatment have been increasing continuously, yet the evidence base remains unc…
Cardiovascular diseases (CVDs) have become one of the leading causes of mortality globally and in China. With lifestyle changes and population aging, the prevalence of CVDs continues to rise, posing substantial challenges to public health. Primary care plays a vital role in the prevention and manage…
Background Wilson's disease (WD) exhibits increased inflammatory levels that are closely associated with cognitive impairment. Studies have demonstrated that activation of the receptor for advanced glycation end products (RAGE)/nuclear factor κB (NF-κB) signaling pathway represents an important infl…
Familial hypercholesterolemia (FH) is a severe inherited metabolic disorder, among which homozygous FH (HoFH) is rare and particularly severe. Early screening, diagnosis, and treatment can substantially improve patient prognosis; however, the recognition and management of HoFH remain severely inadeq…
Background: Osteoporosis (OP) is a systemic bone disease characterized by reduced bone mass, destruction of bone microarchitecture, increased bone fragility, and susceptibility to fracture. China has a large population of OP patients. With advancing age, not only is bone health compromised, but musc…
Background Family doctor contract services have been widely promoted nationwide in China, yet challenges remain in further improving both the contract rate and service quality. Consequently, in-depth investigation and analysis of residents' actual demands for family doctor contract services is of pa…
Osteoporosis is a clinically common skeletal disease triggered by multiple factors. Its primary mechanism involves altering the body's inflammatory microenvironment, promoting increased osteoclastogenesis, which subsequently leads to enhanced bone resorption and decreased bone mass. Paradoxical bone…
Background Locally advanced gastric cancer primarily includes stage III gastric cancer, which is mainly managed with comprehensive therapy. Postoperative recurrence is a key factor affecting patient prognosis. Objective To investigate the factors influencing long-term prognosis in stage III gastric …
Background: In clinical practice, children with Henoch-Schönlein purpura nephritis (HSPN) frequently present with elevated fibrinogen (FIB) levels; however, investigations into the correlation between FIB and renal pathological changes remain limited. Objective: To explore the correlation between FI…
Background: Current research on physical fitness test scores of high school students predominantly focuses on local areas within provinces or cities, with few large-scale, multi-center studies covering entire regions. The widespread implementation of online and offline blended teaching in schools in…
Dysphagia is a common geriatric syndrome with an increasing incidence year by year, which can easily lead to complications such as aspiration pneumonia and asphyxiation. Currently, research on the status quo of dysphagia and its influencing factors in community-dwelling elderly populations is relati…
Cardiovascular disease (CVD) is the leading cause of mortality in China and worldwide, and lipid metabolism disorders are important risk factors for CVD. Understanding the prevalence of dyslipidemia during childhood and adolescence facilitates early prevention of dyslipidemia in adulthood. Objective…
Background Hierarchical medical system is one of the primary objectives of healthcare reform. The Guidance on Promoting the Construction of Hierarchical Medical System (Guobanfa [2015] No. 70) issued by the General Office of the State Council in 2015 proposed that the proportion of outpatient visits…
Background Chronic diseases have become a major public health problem affecting population health. The number of chronic disease patients in China continues to increase, the number of deaths is rising year by year, and the disease burden on patients is gradually intensifying. Understanding the chang…
Background Liver macrophages play crucial roles in constructing host defense mechanisms and maintaining internal environmental homeostasis, and represent important cellular components involved in liver injury and repair. Monocyte-derived macrophages differ from liver resident macrophages in terms of…
Background: In the current rehabilitation environment, emotional problems and cognitive dysfunction in stroke patients are more concealed compared with motor, speech, and swallowing issues, and thus receive insufficient attention in clinical rehabilitation. However, these problems can cause adverse …
