Most papers are machine-translated to English; some are originally in English.
Showing 50 of 79 papers in Medicine, Pharmacy
Abstract Background: The prevalence of neonatal inherited metabolic diseases (IMDs) in China exceeds 0.5%. This study represents the first province-wide screening of neonatal IMDs in Hainan Province, contributing to the prevention and control of birth defects and providing laboratory diagnostic tool…
Analysis and Prediction of Cardiovascular Disease Burden Attributable to Metabolic Risk Factors in China, 1990–2035 Background: Metabolic factors have become the primary driver of the continuous rise in the burden of cardiovascular disease (CVD) in China. Objective: To evaluate the trends in CVD bur…
Abstract Background: Integrated traditional Chinese and Western medicine treatment can effectively alleviate symptoms, inhibit tumor metastasis, and prolong the lives of patients with hepatocellular carcinoma (HCC). In recent years, with the development of evidence-based medicine, the definitive eff…
Abstract Background: The Chinese Visceral Adiposity Index (CVAI) is a novel and simplified metric for evaluating human visceral fat, which is closely associated with cardiovascular and metabolic diseases. Currently, research regarding the correlation between CVAI and diabetes remains limited. Object…
Abstract Background: Colorectal adenoma resection is an effective way to reduce the incidence of colorectal cancer. Currently, the recurrence rate of advanced colorectal neoplasia (ACRN) within 1 year after colorectal adenoma resection is high, and there is a lack of research on the construction of …
Diabetic neuropathy (DN) is the most common and devastating chronic complication of diabetes, among which autonomic neuropathy has garnered significant attention due to its involvement in the dysfunction of multiple organ systems. Pathological mechanisms such as metabolic abnormalities, oxidative st…
Abstract Background: Sarcopenia has a significant impact on the treatment and prognosis of patients with colorectal cancer, and dietary patterns are significantly associated with the condition. Clarifying the correlation between Chinese healthy dietary patterns and sarcopenia is of great significanc…
Background: Subjective cognitive decline (SCD) represents an asymptomatic preclinical stage of Alzheimer's disease (AD). Currently, there is a lack of comparative research in China regarding the status and influencing factors of SCD among elderly populations in urban and rural areas. Objective: To i…
Abstract Background: Against the backdrop of implementing the tiered medical diagnosis and treatment system, joint wards have emerged as an innovative collaborative medical service model to address prominent issues such as the uneven distribution of medical resources and the low utilization of prima…
Abstract Background: In recent years, the issues of overweight and obesity have become increasingly prominent, evolving into a major global public health concern. China has launched the "Weight Management Year" initiative, aiming to prevent and control chronic diseases related to overweight and obes…
The occurrence of acute kidney injury on the basis of multiple coexisting chronic conditions in elderly individuals (also known as "geriatric multimorbidity") is clinically very common. Early and timely intervention with rehabilitation therapy can enhance patients' quality of life and improve clinic…
Abstract Background: In Traditional Chinese Medicine, depression falls under the category of emotional disorders, and its pathogenesis can be explained by the theory of "Interdependence between Kidney and Brain." Whether the Kidney-Tonifying and Brain-Strengthening acupuncture therapy can be used to…
Clinical Efficacy of Chaihu Jia Longgu Muli Decoction Combined with CBT-I for Acute Insomnia of the Liver-Qi Stagnation Transforming into Fire Type Background: Acute insomnia of the liver-qi stagnation transforming into fire type originates from emotional dysregulation, which disturbs the heart and …
Abstract Background: Chronic kidney disease (CKD) is an increasingly severe global public health issue, with its incidence rising annually and showing a close correlation with the development of atherosclerosis. The atherogenic index of plasma (AIP), a simple lipid-based indicator, has been proven e…
Abstract Background: Surgical strategies and the risks of recurrence and metastasis differ significantly between benign and malignant phyllodes tumors of the breast (PTB). Preoperative differentiation between benign and malignant status is crucial for treatment decision-making. Traditional ultrasoun…
Vaccine-preventable diseases impose a heavy health burden on adults, and numerous shortcomings in China's current adult immunization planning urgently need to be addressed and resolved. The "Expert Consensus on Health Promotion Strategies for Adult Vaccination in China" was led by the Institute for …
Vaccine-preventable diseases impose a heavy health burden on adults, and numerous shortcomings in China's current adult immunization planning urgently need to be addressed and resolved. The "Expert Consensus on Health Promotion Strategies for Adult Vaccination in China" was led by the Institute for …
Abstract Background: Colorectal cancer is the malignant tumor with the second highest incidence rate globally. Research indicates that iron metabolism is involved in multiple stages of tumor progression, including tumor cell proliferation and regulation of the immune microenvironment. In clinical pr…
Breast cancer remains one of the most significant global health challenges. Patient survival rates drop drastically when cancer cells spread to adjacent or distant tissues and organs, resulting in distant metastasis. Consequently, early diagnosis and the prediction of malignant potential are critica…
"Medically Unexplained Symptoms" (MUS) has become a significant public health issue. The biomedical interpretation of MUS fails to address the numerous dilemmas faced by individuals with MUS; clinically, problems of overdiagnosis and overtreatment are prominent. Starting from the narrative medicine …
Background: Cardiovascular disease (CVD) poses a severe threat to the life and health of residents, and its prevention and treatment effectiveness largely depend on scientific and rational medical decision-making. With the development of the shared decision-making (SDM) model, patient decision aids …
Abstract Background: As the burden of chronic diseases increases, promoting healthy behaviors among residents has become a critical goal for public health. Despite the gradual improvement in health literacy and management awareness, a significant gap remains between knowledge and behavior. The Behav…
Abstract Background: Resilience can effectively improve health outcomes and enhance the quality of life for adolescents with type 1 diabetes (T1D). However, this population is deeply troubled by multi-source stigma, which severely impairs their resilience. Currently, the mechanism by which different…
Abstract Background: Construction workers face severe mental health challenges, with the prevalence of anxiety, depression, stress, and burnout being significantly higher than in other industries. However, existing research is mostly limited to a "problem-oriented" approach, relying excessively on c…
Background: China is currently leveraging artificial intelligence (AI) technology to enhance the standardization and homogenization of primary health services, driving universal health coverage and demonstrating global leadership in the field of digital health. Objective: To empirically reveal the m…
Abstract Background: Computed tomography-derived fractional flow reserve (CT-FFR) has demonstrated excellent diagnostic performance; however, the consistency between CT-FFR values calculated by different deep learning algorithms has not been evaluated. Objective: This study aims to evaluate the cons…
Abstract Background: With the acceleration of the aging process in China and the increasing complexity of medical service demands, the diseases of hospitalized patients often involve multiple systems and organs. The traditional single-discipline diagnosis and treatment model has become insufficient …
Background Good medication adherence can significantly reduce the risk of recurrence in stroke patients and is critical to secondary prevention in this population. However, existing research has primarily focused on short-term medication use and adherence behaviors among rural stroke patients, while…
Background: The number of clinics in Beijing has increased rapidly; however, clinics face severe challenges, including physician shortages, low service quality, and weak regulatory oversight. Objective: To investigate the operational efficiency of Beijing's clinics and its changing trends, thereby p…
Background Accurate assessment of immune-related adverse events (irAEs) in cancer patients through patient-reported outcomes facilitates early identification of irAEs and timely development and implementation of targeted interventions, which is essential for ensuring continuous treatment and favorab…
Background Currently, six ALK inhibitors (including crizotinib, alectinib, ceritinib, brigatinib, ensartinib, and lorlatinib) have been approved for first-line treatment of ALK-positive advanced non-small cell lung cancer, yet clinical selection remains challenging. Objective To comprehensively eval…
Background Traditional Chinese medicine theory holds that syndrome distribution is closely related to region, but there is currently a lack of clinical studies on the differences in clinical characteristics and syndrome distribution among lung cancer patients in different regions. Objective To analy…
Colorectal cancer, as one of the malignant tumors with persistently high incidence and mortality rates worldwide, poses a serious threat to human health. Moreover, the early diagnosis rate of colorectal cancer is relatively low, and many patients are already in middle and advanced stages at the time…
Background Chinese Visceral Adiposity Index (CVAI) is a novel obesity indicator that has been confirmed to be closely associated with prehypertension and hypertension. However, current research on the correlation between CVAI and nocturnal hypertension (NH) in young and middle-aged adults is lacking…
Background As China's population aging becomes increasingly severe, polypharmacy among older adults is becoming more prevalent, and potentially inappropriate medication (PIM) use is widespread in this population. Objective To investigate PIM and potential prescription omissions in community-dwelling…
Isolated hypothyroxinemia in pregnancy represents a manifestation of thyroid hormone deficiency during gestation, which may impair fetal neurodevelopment and increase the risks of miscarriage, preterm delivery, and gestational diabetes mellitus; however, its underlying mechanisms, optimal therapeuti…
Hypertension is the leading modifiable risk factor for morbidity and mortality from cardiovascular diseases, and accurate blood pressure measurement is a critical factor in hypertension management. Traditional blood pressure measurement has limitations such as being intermittent, static, and unable …
Background Currently, cognitive impairment has become one of the risk factors for disability and death among older adults. Studies have found a correlation between parental literacy and cognitive function, while research on the mediating role of socioeconomic status (SES) between the two is relative…
Overweight and obesity are intimately associated with the pathogenesis of numerous chronic diseases. To address this health crisis, the American College of Sports Medicine published the 'Consensus Statement on Physical Activity and Overweight/Obesity in Adults' in 2024, advocating for the incorporat…
Background: Hypertension is a major chronic disease managed by primary healthcare institutions in China. Cardiac autonomic dysfunction is a primary cause of blood pressure dysregulation and adverse cardiovascular events. Therefore, exploring the relationship between elderly hypertensive patients and…
Background: Idiopathic pulmonary fibrosis (IPF) has a complex pathogenesis, limited treatment options, and poor prognosis, making the search for safe and effective therapeutic targets crucial. Objective: To investigate the regulatory effect of Neuropilin-1 (Nrp1) on mouse pulmonary fibroblast (MPF) …
Background Chronic obstructive pulmonary disease (COPD) is one of the major diseases that seriously threaten public health in China. Owing to the specific structural and functional characteristics of the kidneys, COPD patients are prone to renal function impairment; however, research on the related …
The impact of cardiovascular diseases (CVD) and their risk factors on population health is becoming increasingly prominent, with the incidence of CVD continuing to rise. The economic burden imposed by CVD on both individuals and society is mounting, constituting a major public health challenge that …
Poor sleep in older adults is closely associated with multiple health outcomes. If primary healthcare institutions strengthen sleep health and rehabilitation management on the basis of existing elderly health management, it will help prevent and delay the onset and progression of many chronic diseas…
Background The irrational use of antibiotics among pediatric patients and their parents following hospital discharge represents a significant problem. Providing accurate antibiotic medication guidance and educational outreach to children and parents constitutes a crucial intervention for improving p…
Background Hearing loss is a common health issue among middle-aged and elderly individuals, affecting quality of life and social interaction, and is associated with the risk of cognitive decline. In recent years, population aging in China has intensified, with the proportion of middle-aged and elder…
Background Nervous system diseases severely impair patients' quality of life, with complex etiologies involving multiple factors such as genetics, infection, and immunity. In recent years, research on the involvement of gut microbiota in the pathogenesis and progression of nervous system diseases vi…
Ischemic stroke, as one of the leading causes of disability and mortality worldwide, has witnessed significant advances in research on prognostic biomarkers in recent years. This study reviews the mechanisms of action and research progress on the utility of various biomarkers, including hematologica…
Cardiovascular disease is one of the major diseases threatening women's health, and postmenopausal women are a high-risk population for cardiovascular disease. The decline in estrogen levels after menopause may promote the accumulation of visceral fat, and increased visceral fat is closely associate…
Background Hemorrhoids are the most common disease in anorectal surgery, with a large patient population. The integrated traditional Chinese and Western medicine approach demonstrates significant advantages in clinical practice. Currently, there is a lack of high-quality guidelines or recommended st…
