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Theta-Gamma Phase-Amplitude Coupling in the Prefrontal-Hippocampal-Medial Septal Circuit: Mechanisms of Cross-Regional Coordination and Working Memory Regulation

Zhang Qiuxia, Chen Weihai, Chen Weihai
2025-10-31 ChinaXiv: chinaxiv-202511.00021 Mixed Source

As the core of high-level cognitive functions, working memory relies on the dynamic synergy of the prefrontal-hippocampal-medial septal neural circuit, in which theta-gamma phase-amplitude coupling (TG-PAC) serves as a key mechanism for cross-regional information integration. This paper systematical…